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E. increase bradykinin concentration in the blood

17. Which of the following drugs is not suitable to treat the patient with angina pectoris accompanied with asthma? A. nifedipine B. propranolol C. nitroglycerin D. verapamil

E. isosorbide dinitrate

18. The drug choice for ventricular

arrhythmia caused by cardiac glycosides poisoning is A. propranolol

B. sodium phenytoin C. quinidine D. amiodarone E. procainamide

19. Which of the following mechanism best accounts for the decreasing blood sugar effect of glibenclamide? A. stimulating βcell

in pancreatic island directly, promopting the release of insulin

B. inhibit the activity of α－glycosidase C. decreasing the absorptiong of glulose D. increase the sensitivity of insulin to target organism

E. directly activiting insulinreceptors

20. Which of the following statements about the treatment of chronic heart failure is wrong?

A. patients with evidence of fluid retention should receive a diuretic.

B. treatment with an ACE inhibitor and a βR

blocker should be initiated and maintained unless specifically contraindicated.

C. digoxin may be added if needed to

reduce symptoms or to slow the ventricular response in patients with rapid atrial fibrillation. D. patients with severe heart failure should also receive a βR blocker

E. spironolactone may reduce mortality in patients with severe heart failure 21. A 76yearold

male with CHF and hearing loss is given a diuretic as part of a

regimen that includes digoxin and an ACE inhibitor. In the course of treatment, he develops an AV conduction defect and is found to be hypomagnesemic. She also has worsening hearing loss, which is

reversed when the drug stopped. Which of the following diuretics did she used? A. furosemide

B. hydrochlorothiazide C. spironolactone D. amiloride E. mannitol 22. A 70yearold

female is treated with sublingual nitroglycerin for her occasional

bouts of angina. Which of the following is involved in the action of nitroglycerin? A. αadrenergic activity

B. phosphodiesterase activity

C. phosphorylation of light chains of myosin

D. norepinephrine release E. cGMP increased 23．A 56yearold

female has recently developed essential hypertension, for which

she is receiving chlorothiazide to lower her blood pressure. Which of the following ions would not increasing concentration in her urine? A. K + B. Cl C．Ca 2+ D. Na + E. Mg 2+

24. A 58yearold

patient with a history of hypertension and congestive heart

failure administrating some drugs, now he complains of nausea, blurred vision

and bradycardia, intoxication of glycoside is suspected, then digoxin is stopped,

which of the following drugs also must be stopped? A. nifedipine B. diazoxide

C. hydrochlorothiazide D. prazosin E. clonidine

25. Which of the following disease can be treated with large dose of iodium ? A. cretinism B. solid edema C. endemic goiter D. thyroid crisis E. mild thyroidism

26. The appropriate target in the nephron of furosemide is

A. Na + /K + /2Cl cotransporter

of the luminal membrane in the ascending limb of

Henle’s loop

B. Na + /2Cl cotransporter

of the luminal membrane in the distal tubule

C. competes with aldosterone for

intracellular cytoplasmic receptor sites D. Na + /H + exchanger of the luminal membrane in collecting duct

E. carbonic anhydrase of proximal tubule 27. Being antagonizing 5HT3

receptor, the drug with significant effect against vomiting is A．cimetidine B．promethazine C．ondansetron D．ranitidine E. nizatidine 28. Vit K is a substance to prevent or reduce bleeding caused by A. heparin B. aspirin C. urokinase D. streptokinase E. dicoumarin

29. Which of the following mechanisms best accounts for the antithyroid effect of

methylthiouracil？

A. inhibiting peroxidase and decreasing the thyroxin synthesis

B. inhibiting the thyroid releasing C. inhibiting the absorption of iodine

D. interfering with the utilization of iodine E. decomposing the thyroxin 30. A 60yearold

diabetic male is treated with pioglitazone. What is the

mechanism of pioglitazone ?

A. increased release of endogenous insulin B. decreased plasma glucagon levels C. increased hepatic gluconeogenesis D. increased target tissue sensitivity to insulin

E. decreased intestinal absorption of glucose

31. Which of the following is the most important approach in preventing peptic ulcers from recurrence? A. coating the ulcer crater

B. eradicating infection with H. Pylori

C. inhibiting secretion of gastric acid at the proton pump

D. blocking receptor activation of gastric acid secretion

E. neutralizing secreted gastric acid

32. Which of the following statements about insulin is NOT true?

A. It can cause hyperglycemic reaction B. It can’t be administrated orally C. Its mechanism of action is through intracellular receptor pathway

D. It can be used in IDDM and NIDDM E. It can cause anaphylactic reaction 33. All of the following are indications of glucocorticoids EXCEPT A. rheumatic arthritis B. bronchial asthma C. peptic ulcer D. endotoxic shock

E. childhood acute leukemia 34．Which of the following statements about heparin is true ?

A. mild anticoagulative effect B. slow onset of effect

C. no anticoagulative effect in vitro

D. possessing anticoagulative effect in vitro E. It can be administrated orally

35. The antiasthmatic effect of salbutamol is attributed to

A．stimulation of β2 receptor B．blockade of Mreceptor

C．activation of guanylate cyclase D．increase of intracellular cGMP E．inhibition of phosphodiesterase

36. Which of the following therapies is the best for a patient with status asthmaticus?

A．aminophylline p.o. B．hydrocortisone i.v.

C．inhaling sodium cromoglycate D．inhaling beclomethasone E．salbutamol p.o. 37. A 75yearold

woman is hospitalized for pneumonia and treated with an

intravenous antibiotic, on the 3rd day, she developed serious diarrhea, stool is positive for Clostridium difficile toxin. What is the best treatment? A. clindamycin B. cefaclor

C. metronidazole D.erythromycin E. chloramphenicol 38. A 35yearold female complains of itching in the vulval area, examination of

the urine reveals trichomonads, what is the preferred treatment for trachomoniasis? A. doxycycline B. ofloxacin C. piperacillin D.metronidazole E. chloramphenicol

39. All of the following statements about antibiotics are accurate except

A. the cephalosporins inhibit cell wall synthesis by inhibiting βlactamases

B. tetracyclines inhibit protein synthesis of bacterial by interacting with the 30s ribosomal subunit.

C. aminoglycosides inhibit protein synthesis of bacterial by interacting with the 30s ribosomal subunit.

D. polymyxins act to disrupt the selective permeability of bacterial cell

membranes by insertion into the lipid bilayer.

E. trimethoprim inhibits dihydrofolate reductases of bacteria.

40. Which of the following agents is NOT an antimetabolite?

A. cytarabine（AraC）

B. cyclophosphamide（CTX） C. fluorouracil （5FU） D. methotraxate（MTX） E. mercaptopurine（6MP）

41. Which of the following drugs can be used to treat AIDS? A. acyclovir B. zidovudine C. ribavirin D. idoxuridine E. vidarabine

42. Which of the following antibiotics is most effective against infection caused by Methicillin resistant

staphylococcus aureus（MRSA）?

A. erythromycin B. vancomycin C. streptomycin D. ofloxacin E. imipenem

43. Which of the following agents may cause damage to growing cartilage? A. floroquinolones B. sulfonamides C. aminoglycosides D. cephalosporins E. tetracyclines

44. Why is vitamin B6 usually prescribed with isoniazid(INH)?

A. it acts as a cofactor of isoniazid

B. it prevents some adverse reaction of INH therapy

C. it has antituberculosis effect D. it prevents metabolism of INH E. it decreases the occurrence of drug resistance

45. Common properties of aminoglycoside antibiotics include all of the following except

A. poor absorption after oral administration

B. extensive metabolism in vivo

C. dependence on glomerular filtration for their elimination

D. commonly produce ototoxicity E. commonly produce nephrotoxicity 46. A 30yearold

male diabetic with renal complications develops acute nephritis, 10

P.aeruginosa is found in urine cultures and blood cultures. Combined therapy is instituted with an aminoglycosides and which of the following? A. clavulanic acid B. a secondgeneration cephalosporin C. azithromycin D. piperacillin

E. vancomycin

47. A young woman using an oral contraceptive is to be treated for pulmonary

tuberculosis. She is advised to use an additional method of contraception since the

efficacy of the oral agent is commonly decreased if her drug regimen includes A. streptomycin B. ethambutol C. rifampin D. isoniazid

E. pyrazinamide

48. Which of the following drugs is the drug choice in the treatment of severe fungal pneumonia or cryptococcal meningitis? A．terbinafine B．griseofulvin C．amphotericin B D．flucytosine E．ketoconazole

49. All of the following antibiotics act by interfering with protein synthesis except A．doxycycline B．amikacin

C．chloramphenicol D．cefaclor E．clindamycin

50. Erythromycin can not be used for patients with

A. mycoplasmal pneumonia B. legionella pneumonia C. diphtheria D. typhoid E. pertussis

Type X choice questions (one or more answers may be correct)

51. Which of the following drugs belong to the firstline

drugs therapy for

hypertension in current?

A. a vasodilator such as hydralazine

B. a cardiac glycoside such as digoxin C. a βreceptor

blocker such as propranolol D. a thiazide diuretic such as hydrochlorothiazide

E. an ACE inhibitor such as captopril 52．Which of the following is (are) not the indication of mannitol? A. cerebral edema B. glaucoma

C. preventing acute renal failure D. congestive heart failure E. oliguria caused by shock 53．Which of the following statements about amiodarone are (is) true? A. it increases APD and ERP

B. it blocks α and βadrenoreceptors C. it can cause pulmonary fibrosis D. it can cause hyperor hypothyroidism

E. it has reverse usedependence

54. Which of the following diseases are the contraindictions of glucocorticoids? A. fulminant epidemic cerebrosonial meningitis B. psychosis

C. diabetes mellitus D. severe hypertension E. chickenpox

55.Which of the following drugs is useful in treating diabetes

mellitus after the excision of pancreas? A. tolbutamide B. phenformin C. glibenclamide D. insulin E. gliclazide

56. Which of the following statements about dicumarol is (are) true?

A.Vitamin K is its competitive antagonist B. It can inactivate coagulant factor Ⅱa, Ⅶa, Ⅸa, Ⅹa

C. It is effective in vivo, not in vitro

D. Cimetidine can weaken its anticoagulant effect

E. It can inhibit the aggregation of platelet 57. Metronidazole can be used in the treatment of A. Syphilis

B. Trichomonas vaginalis infection C. Bacterial dysentery D. Anaerobic infections 12

E. Helicobacter pylori infection

58. A young woman with pregnancy should avoid using which of the following drugs to treat urinary tract infection caused by gramnegative rods?

A. gentamicin B. ceftriaxone C. ofloxacin D. tetracycline E. SMZco

59. Quinolones can NOT be used in the patients who

A. have epilepsy history

B. are in growth and development period C. are taking antiacid D. are pregnant

E. are allergic to penicillin

60. Which of the following clinical

indications may require a combination of antibiotics?

A. treatment of mixed infections B. treatment of tuberculosis

C. treatment of cryptococcal meningitis D. treatment of gonorrhea

E. treatment of severe infections of unknown origin 二、 选择题 单选：

1．C 2.A 3.E 4.D 5.C 6.C 7.B 8.E 9.D 10.D 11.B 12.C 13.B

14.B 15.E 16.D 17.B 18.B 19.A 20.D 21.A 22.E 23.C 24.C 25.D

26.A 27.C 28.E 29.A 30.D 31.B 32.A 33.C 34.D 35.A 36.B 37.C