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兰州理工大学石油化工学院毕业设计(论文)

LANZHOU UNIVERSITY OF TECHNOLOGY

毕业设计(论文)

题 目 年产9.0吨7-ACT工艺设计

学生姓名 周 兴 平 学 号 10190125 专业班级 应用化学（1）班 指导教师 欧 玉 静 学 院 石油化工学院 答辩日期 2014.06.16

兰州理工大学石油化工学院毕业设计(论文)

摘要

本设计的主要任务是完成年产量为9.0吨7-ACT生产车间工艺设计。根据河南圣凡制

药有限公司头孢曲松钠车间的生产工艺，通过查阅相关文献，参考其他生产工艺，结合实际的情况及毕业设计要求设计了7-ACT的生产工艺。本设计对头孢曲松钠中间体7-ACT的多种合成途径进行了研究，在实际生产中，以7-ACA和三嗪环为原料，经过反应、结晶、离心、粉碎、干燥得到头孢曲松钠药物中间体7-ACT。根据流程对反应釜、养晶罐、离心机、干燥器进行物料、能量衡算，根据计算结果以及相关设备标准进行设备选型、管道配置等。并依据所选设备绘出带控制点的工艺流程图、物料流程图，编制物料及热量平衡表。此外，还对主要设备反应釜进行了设计，包括筒体、封头、人孔、支座、夹套、搅拌轴转速等，在简单计算的基础上确定了反应釜的基本几何尺寸，并根据计算的尺寸绘制了反应釜的剖面图。

关键词:7-ACT；工艺设计；反应釜

兰州理工大学石油化工学院毕业设计(论文)

Abstract

The main task of this design is to complete the annual output of 9.0 tons of 7 - ACT

production workshop process design. According to HeNan SAN pharmaceutical co., LTD., ceftriaxone sodium workshop production craft, by consulting relevant literature, reference other production technology, combined with the actual situation and the graduation design requirements 7 - ACT's production process is designed. This design of ceftriaxone sodium intermediates 7 - ACT of a variety of synthetic ways are studied, in the actual production, 7 - ACA and triazine ring as raw material, after the reaction, crystallization, centrifugal, crushing, drying for 7 - ACT ceftriaxone sodium drug intermediates. According to the process of the reaction kettle, a tank, centrifuge, dryer for material and energy balance, according to the results of calculation and related equipment standards for equipment selection, pipe configuration, etc. According to the selected equipment draw with control points of process flow diagram, material flow diagram, prepare the material and heat balance. In addition, the reaction kettle of the main equipment is designed, including cylinder, head, manhole, bearing, jacket, stirring shaft speed, etc., on the basis of simple calculation to determine the basic geometry of the reaction kettle, mapped the reaction kettle and according to the calculation of the size of section.

Key words: 7 - ACT; Process design; The reaction kettle

兰州理工大学石油化工学院毕业设计(论文)

目录

1.引言 ...................................................................... 1

1.1产品介绍 ............................................................ 1 1.2设计的目的和意义 .................................................... 1 1.3头孢曲松钠工艺研究 .................................................. 2 1.4车间“三废”治理和环境保护 .......................................... 2 2.物料衡算 .................................................................. 3

2.1反应工段的物料衡算 .................................................. 3 2.2养晶工段的物料衡算 .................................................. 4 2.3离心机的物料衡算 .................................................... 6 2.4干燥器的物料衡算 .................................................... 7 3能量衡算 .................................................................. 9

3.1预热阶段的反应釜的能量衡算 .......................................... 9 3.2反应工序的能量衡算 .................................................. 9 4.主要设备选型 ............................................................. 11

4.1反应釜选型 ......................................................... 11 4.2养晶罐选型 ......................................................... 11 4.3离心机选型 ......................................................... 12 4.3干燥器选型 ......................................................... 12 5关键设备设计 ............................................................. 13

5.1反应釜简介 ......................................................... 13 5.2罐体几何尺寸的计算 ................................................. 14

5.2.1反应釜体积计算 ............................................... 14 5.2.2夹套几何尺寸计算 ............................................. 15 5.3反应釜搅拌装置设计 ................................................. 17

5.3.1叶轮尺寸的确定 ............................................... 17 5.3.2叶轮离釜底高度Hi的确定 ...................................... 17 5.3.3叶轮叶片宽度W的确定 ......................................... 17 5.3.4叶轮叶片长度l的确定 ......................................... 17 5.3.5液体深度HL的确定 ............................................ 18 5.3.6搅拌器转速的计算 ............................................. 18 5.3.7搅拌轴临界转速校核计算 ....................................... 18 5.3.8搅拌轴长的确定 ............................................... 18 5.3.9计算L1 ....................................................... 18 5.3.10计算L2 ...................................................... 19 5.3.11计算浸入液体搅拌轴的长度L3 .................................. 19 5.4挡板参数的确定 ..................................................... 19

5.4.1挡板数目的确定 ............................................... 19 5.4.2挡板长度li的确定 ............................................ 19 5.4.3挡板宽度Wb的确定 ............................................ 19

兰州理工大学石油化工学院毕业设计(论文)

5.5釜体厚度计算 ....................................................... 19

5.5.1筒体厚度计算 ................................................. 19 5.5.2封头厚度计算 ................................................. 20 5.5.3夹套厚度计算 ................................................. 20 5.6附件的选择 ......................................................... 20

5.6.1接管选择 ..................................................... 20 5.6.2视镜 ......................................................... 21 5.6.3支座 ......................................................... 21 5.6.4手孔与人孔 ................................................... 21 5.6.5轴封装置的选择 ............................................... 21

致谢 ....................................................................... 22 参考文献 ................................................................... 23 附录A: 外文资料 ........................................................... 24 Chapter6 EXPERIMENTAL EQUIPMENT AND PROCEDURES .................... 24

6. 1 Description of the 42 l continuous crystallizer and the fluidized bed. ..........................................24

6. 2 Measurement of the concentration，supersaturation and solubility .........................26 6.3 Thermodynamics of separation operations .............................................27

6.3.1Energy, entropy, and availability balances ...................................... 27

附录B: 外文翻译 ........................................................... 29 6.实验过程分析 ............................................................. 29

6.1 .42L连续结晶生产过程和流化床 ...................................... 29 6.2溶解度、饱和度和浓度的测量 ......................................... 30 6.3热力学分离操作 ..................................................... 31

6.3.1能量、熵和可用性平衡 ......................................... 31